Consort study opioid

Trends in De-facto Long-term Opioid Therapy for Chronic ...

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CONSORT (CONsortium to Study Opioid Risks and Trends) includes adult enrollees of two health plans serving over one-percent of the US population. Using automated data, we constructed episodes of opioid use between 1997 and 2005. We estimated age-sex standardized rates of opioid use episodes ...

Trends in De-facto Long-term Opioid Therapy for Chronic ...

Age and Gender Trends in Long-Term Opioid Analgesic Use ...

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The CONSORT study (Consortium to Study Opioid Risks and Trends) was developed to investigate trends and risks of long-term opioid therapy for noncancer pain from 1997 to 2005. Details of the methods have been published previously 23; we briefly describe the study population and methods.

Age and Gender Trends in Long-Term Opioid Analgesic Use ...

Postsurgical prescriptions for opioid naive patients and ...

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have called for study into this issue6 15 16 to underpin future guidelines.17 Furthermore, evidence shows that any post-discharge use is a risk factor for multiple refills18 independent of the specific prescription.19 In this study, we examined the association between opioid prescription refills after surgery and misuse in an opioid naive ...

Postsurgical prescriptions for opioid naive patients and ...

Study: Opioid prescribing for non-cancer pain increases

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9/16/2013 · Prescribing of strong opioid medications for non-cancer pain in the United States has nearly doubled over the past decade, reports a study in the October issue of Medical Care, published by ...

Study: Opioid prescribing for non-cancer pain increases

Depression and Prescription Opioid Misuse Among Chronic ...

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The CONSORT study (CONsortium to Study Opioid Risks and Trends), funded by the National Institute for Drug Abuse, was initiated to study COT for chronic noncancer pain among adults. The study took place at Group Health Cooperative (GHC) in Washington State and Kaiser Permanente of Northern California (KPNC).

Depression and Prescription Opioid Misuse Among Chronic ...

(PDF) Opioid Prescriptions for Chronic Pain and Overdose A ...

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Opioid Prescriptions for Chronic Pain and Overdose A Cohort Study. ... We report findings from the CONSORT (Consor- ... (CONsortium to Study Opioid Risks and Trends) includes adult enrollees of ...

(PDF) Opioid Prescriptions for Chronic Pain and Overdose A ...

The Economic Impact of Opioid Use in the Management of ...

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Summary Chronic nonmalignant pain (CNMP), defined as persistent pain that is not attributable to a potentially life-limiting condition and has a duration of at least 3 months, is widespread in the United States. Moderate-to-severe CNMP often is treated with opioid analgesics, and there is ongoing debate regarding appropriate allocation of opioids to treat CNMP because long-term treatment can ...

The Economic Impact of Opioid Use in the Management of ...

Depression and Prescription Opioid Misuse Among Chronic ...

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study was to identify other clinical variables associated with misuse. METHODS The CONSORT study (CONsortium to Study Opioid Risks and Trends), funded by the National Institute for Drug Abuse, was initiated to study COT for chronic noncancer pain among adults. The study took place at Group Health Cooperative (GHC) in Washington State

Depression and Prescription Opioid Misuse Among Chronic ...

A Longitudinal Study of Depression among Middle-aged and ...

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Methods: We prospectively assessed patients 45 years or older initiating chronic opioid therapy (COT) at baseline and at 4 and 12 months, differentiating recent COT...

A Longitudinal Study of Depression among Middle-aged and ...

The Economic Impact of Opioid Use in the Management of ...

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Consortium to Study Opioid Risks and Trends (CONSORT) study, which examined opioid use in the United States using pooled insurance data comprising greater than 1% of the U.S. population, found the prevalence of long-term opioid use— defined as more than 120 days of dispensed medication for CNMP—to be between 3.9% and 4.7%.13 While drug ...

The Economic Impact of Opioid Use in the Management of ...

De Facto Long-term Opioid Therapy for Noncancer Pain

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Abstract Objectives This paper describes characteristics of opioid use episodes for noncancer pain and defines thresholds for de facto long-term opioid therapy. Methods CONSORT (CONsortium to Study Opioid Risks and Trends) includes adult members of 2 health plans serving over 1% of the US population. Opioid use episodes beginning in the years 1997 to 2005 were classified as acute, episodic ...

De Facto Long-term Opioid Therapy for Noncancer Pain

Opioid therapy for chronic pain in the United States ...

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The CONSORT study (CONsortium to Study Opioid Risks and Trends) looked at claims data from 2 health maintenance organizations, Group Health in Washington State and Kaiser Permanente of Northern California, between 1997 and 2005. Both studies used chart diagnosis to assess for the presence of chronic pain conditions, ...

Opioid therapy for chronic pain in the United States ...

The missing ‘P’ in pain management: how the current opioid ...

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Braden et al. reported a linkage between depression and long-term (> 90 days) opioid use episodes as a part of the CONsortium to Study Opioid Risks and Trends (CONSORT) study. The report looked at claims data from Group Health in Washington State and Kaiser Permanente of Northern California between 1997 and 2005, and found that, compared to ...

The missing ‘P’ in pain management: how the current opioid ...

Deep Learning Solutions for Classifying Patients on Opioid Use

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Deep Learning Solutions for Classifying Patients on Opioid Use Zhengping Che1, Jennifer St. Sauver, PhD 2, Hongfang Liu, PhD , Yan Liu, PhD1 1Department of Computer Science, University of Southern California, Los Angeles, CA 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN Abstract Opioid analgesics, as commonly prescribed medications used for relieving pain in patients, …

Deep Learning Solutions for Classifying Patients on Opioid Use

EML OPIOIDS FOR CANCER PAIN: A COMPARATIVE OVERVIEW ...

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Figure 1. Consort-Like diagram of selected papers for efficacy. 72 Summary of data for Efficacy (Table 1, Appendix 5). 73 Randomized Controlled Trials (Table 2, Appendix 5). 74 Systematic Review (Table 3, Appendix 5). 75 Prospective Open Label Study (Table 4, Appendix 5). 76 References 77 Toxicity of Tramadol in clinical studies. 78 Figure 1.

EML OPIOIDS FOR CANCER PAIN: A COMPARATIVE OVERVIEW ...

Trends in long-term opioid therapy for chronic non-cancer ...

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Methods—CONSORT (CONsortium to Study Opioid Risks and Trends) includes adult enrollees of two health plans serving over one-percent of the US population. Using automated data, we constructed episodes of opioid use between 1997 and 2005. We estimated age-sex standardized rates of opioid use episodes beginning in each year (incident) and on ...

Trends in long-term opioid therapy for chronic non-cancer ...

Study protocol for a pragmatic trial of the Consult for ...

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Treatment for opioid use disorder (OUD) is highly effective, yet it remains dramatically underutilized. Individuals with OUD have disproportionately high rates of hospitalization and low rates of addiction treatment. Hospital-based addiction consult services offer a potential solution by using multidisciplinary teams to evaluate patients, initiate medication for addiction treatment (MAT) in ...

Study protocol for a pragmatic trial of the Consult for ...

Michael J. Silverberg, PhD, MPH NIH Public Access G ...

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Study setting, design and population The analysis was performed within the CONsortium to Study Opioid Risks and Trends (CONSORT)15, which has the overall study goal to examine determinants and risks of long-term opioid therapy among for the treatment of chronic non-cancer pain. Eligible subjects

Michael J. Silverberg, PhD, MPH NIH Public Access G ...

Single high-dose buprenorphine for opioid craving during ...

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12/10/2018 · Methods. Ninety men who used opium, heroin, or prescribed opioids and met DSM-5 criteria for opioid use disorder (severe form) were randomized to three groups (n = 30 per group) to receive a single, sublingual dose of buprenorphine (32, 64, or 96 mg).The study was conducted in an inpatient psychiatric ward, with appropriate precautions and monitoring of respiratory and cardiovascular …

Single high-dose buprenorphine for opioid craving during ...

Opioid prescribing decreases after learning of a patient’s ...

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8/10/2018 · Most people addicted to opioids began taking them because they were legally prescribed. Little attention has been paid to changing physicians' prescribing behavior. Using a randomized controlled trial format, Doctor et al. monitored the effect of notifying physicians who had a patient die of opioid overdose within 12 months of a prescription.

Opioid prescribing decreases after learning of a patient’s ...

Suboxone Treatment and Recovery Trial (STAR-T): Study ...

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Introduction. Opioid assisted treatment (OAT) with buprenorphine (BUP) is front-line medical maintenance intervention for illicit and prescription opioid use disorder (OUD). In many clinics, opioid medication is dispensed for several days for self-administration. This provides flexibility to the patient but may compromise the effectiveness of OAT because of nonadherence or medication diversion.

Suboxone Treatment and Recovery Trial (STAR-T): Study ...

POFA trial study protocol: a multicentre, double-blind ...

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6/1/2018 · Methods/analysis The POFA trial is a prospective, randomised, parallel, single-blind, multicentre study of 400 patients undergoing elective intermediate or major non-cardiac surgery. Patients will be randomly allocated to receive either a standard anaesthesia protocol or an OFA. The primary outcome measure is the occurrence of a severe postoperative opioid-related adverse event within the ...

POFA trial study protocol: a multicentre, double-blind ...

Current Guidelines on Appropriate Prescribing and Tapering ...

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Goal for Opioid Taper? 31 CONSORT Study (Dunn 2010) Study Retrospective, observational study set in 29 clinics Inclusion criteria Age 18-99 initiating new episode of opioid use between 1997 and 2005 3+ Rx for opioid analgesics in the first 90 days of the episode Diagnosis of …

Current Guidelines on Appropriate Prescribing and Tapering ...

Do Patient-perceived Pros and Cons of Opioids Predict ...

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which patients on opioid therapy will sustain use of opioids long-term, and none have addressed sustained higher-dose use. A study of the workers’ compensation pharmacy bills of 781 workers who received opioid prescriptions within the first year after a work-related back injury found that opioid dose in the first quarter after injury ...

Do Patient-perceived Pros and Cons of Opioids Predict ...

Functional Disability Among Chronic Pain Patients ...

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METHOD Study Sites The Consortium to Study Opioid Risks and Trends (CONSORT) is a study developed to improve understanding of long-term opioid therapy for chronic noncancer pain among adults in the Group Health Cooperative (GHC) in the state of Washington, and Kaiser Permanente of Northern California (KPNC; Von Korff et al., 2008).

Functional Disability Among Chronic Pain Patients ...

Low-dose memantine attenuated methadone dose in opioid ...

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5/19/2015 · Study Participants. One hundred eighty opioid-dependent patients were screened for eligibility (See Fig. 1 for the CONSORT Flow Diagram). Forty-six of those screened declined to participate ...

Low-dose memantine attenuated methadone dose in opioid ...

Annals of Internal Medicine Article - RSDSA

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We report findings from the CONSORT (Consor-tium to Study Opioid Risks and Trends) study (22). The study setting was Group Health Cooperative (GHC), which provides comprehensive care on a prepaid basis to about 500 000 persons in Washington (23). The study was approved by the GHC Institutional Review Board. Sample

Annals of Internal Medicine Article - RSDSA

Evaluation of Opioid Modulation in Major Depressive ...

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12/18/2014 · CONSORT flow diagrams. In Study 1, opioid-experienced adults received single doses of BUP/SAM 8/0 mg, 8/1 mg, and 8/4 mg in Cohort 1 and 8/0 mg, …

Evaluation of Opioid Modulation in Major Depressive ...

NEUROSCIENCE Opioid prescribing decreases after learning ...

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NEUROSCIENCE Opioid prescribing decreases after learning of a patient’s fatal overdose Jason N. Doctor 1*, Andy Nguyen , Roneet Lev2, Jonathan Lucas3, Tara Knight , Henu Zhao1, Michael Menchine4 Most opioid prescription deaths occur among people with common conditions for which

NEUROSCIENCE Opioid prescribing decreases after learning ...

Opiant Pharma, Consort Medical to Manufacture OPNT003 for ...

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Opiant Pharmaceuticals (OPNT), a specialty pharmaceutical company, and Consort Medical, a contract development and manufacturing organization, unveiled on Monday a development and manufacturing agreement for Opiant’s OPNT003 (intranasal nalmefene), a potent, long-acting opioid antagonist for the treatment of opioid overdose.

Opiant Pharma, Consort Medical to Manufacture OPNT003 for ...

Opiant Pharmaceuticals signs manufacturing agreement with ...

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9/10/2018 · Opiant Pharmaceuticals signs manufacturing agreement with Consort Medical for OPNT003 for treatment of opioid overdose ... study in early 2019 and anticipates a NDA for the drug and intranasal ...

Opiant Pharmaceuticals signs manufacturing agreement with ...

American Gastroenterological Association Institute ...

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This document presents the official recommendations of the American Gastroenterological Association (AGA) on the medical management of opioid-induced constipation. The guideline was developed by the AGA Institute’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a technical review that is a compilation of clinical evidence from which these ...

American Gastroenterological Association Institute ...

Serious adverse events reported in placebo randomised ...

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Naltrexone is an opioid antagonist used in many different conditions, both licensed and unlicensed. It is used at widely varying doses from 3 to 250 mg. The aim of this review was to extensively evaluate the safety of oral naltrexone by examining the risk of serious adverse events and adverse events in randomised controlled trials of naltrexone compared to placebo.

Serious adverse events reported in placebo randomised ...

Consort, Opiant to develop nasal spray for opioid overdose ...

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9/10/2018 · Consort, Opiant to develop nasal spray for opioid overdose treatment California-based Opiant earlier this year was awarded a $7.4 million grant …

Consort, Opiant to develop nasal spray for opioid overdose ...

REVIEW OF THE EVIDENCE FOR THE EFFICACY AND …

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REVIEW OF THE EVIDENCE FOR THE EFFICACY AND EFFECTIVENESS OF OPIOID ANALGESICS ... epidemiological study Pain, 2006;125:172-9 228 opioid users compared with 1,678 non-opioid users. ... CONSORT data 56% of lower dose users (<50 mg MED) are working compare to 39% of moderate ...

REVIEW OF THE EVIDENCE FOR THE EFFICACY AND …

Consort Medical to manufacture Opiant’s nalmefene nasal spray

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Consort Medical subsidiaries Aesica and Bespak will manufacture Opiant Pharmaceuticals’ OPNT003 nalmefene nasal spray, the companies said. Earlier this year, Opiant announced that it would develop OPNT003 for the treatment of opioid overdose using the 505(b)(2) pathway, and the company has been awarded a grant worth around $7.4 million by the National Institutes of Health’s National ...

Consort Medical to manufacture Opiant’s nalmefene nasal spray

PANSAID – PAracetamol and NSAID in combination: study ...

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1/10/2017 · PANSAID is a randomised multicentre trial with a central computer-generated allocation sequence, concealed allocation, blinding of assessors, investigators, caregivers, patients and statisticians in patients having an elective total hip arthroplasty (Fig. 1).Patients will be randomised with varying block size and stratified according to site for treatment groups receiving either paracetamol ...

PANSAID – PAracetamol and NSAID in combination: study ...

Opioids for Chronic Pain and Addiction Treatment

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Opioids for Chronic Pain and Addiction Treatment Joseph Merrill M.D., M.P.H. University of Washington February 24, 2012 ... CONSORT STUDY CON sortium to Study Opioid Risks & Trends PI Michael Von Korff Aims Study trends in long-term opioid use 1997-2005 Assess risks of adverse events Assess the risks of misuse and psychosocial problems among

Opioids for Chronic Pain and Addiction Treatment

Opiant Pharmaceuticals, Inc. and Consort Medical plc ...

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About Consort Medical plc. Consort Medical plc is a leading, global, single source pharma services drug and delivery device company. Consort is at the leading edge of innovation and is committed to investing in patient, clinician and customer driven innovation to create new treatments, new markets and new opportunities. Consort’s businesses:

Opiant Pharmaceuticals, Inc. and Consort Medical plc ...

Consort, Opiant to develop nasal spray for opioid overdose ...

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(Reuters) – Britain’s Consort Medical Plc said on Monday it had agreed to develop a nasal spray for treating opioid overdoses with specialty pharmaceutical company Opiant Pharmaceuticals Inc. California-based Opiant earlier this year was awarded a $7.4 million grant by the U.S. National ...

Consort, Opiant to develop nasal spray for opioid overdose ...

Buprenorphine/naloxone versus methadone and lofexidine in ...

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Buprenorphine/naloxone, methadone and lofexidine are medications with utility in the treatment of opiate withdrawal. We report the first randomised controlled trial to compare the effects of these two medications on withdrawal symptoms and outcome during opiate induction/stabilisation and detoxification. A double-blind randomised controlled trial was conducted in an outpatient satellite clinic ...

Buprenorphine/naloxone versus methadone and lofexidine in ...

[Full text] Efficacy of opioids versus placebo in chronic ...

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12/19/2017 · Opioid efficacy was statistically significant (p<0.001) versus placebo for pain intensity (standardized mean difference: −0.416), ≥30% and ≥50% improvement in pain (risk difference: 0.166 and 0.137), patient global impression of change (0.163), and patient global assessment of study medication (0.194). There were minor benefits on ...

[Full text] Efficacy of opioids versus placebo in chronic ...

A nonaddictive opioid painkiller with no side effects

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1/5/2018 · "A nonaddictive opioid painkiller with no side effects" Man, ... which eventually lead to the above CONSORT (CONsortium to Study Opioid Risks and …

A nonaddictive opioid painkiller with no side effects

Incident and long-term opioid therapy among patients with ...

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Similarly, in the CONSORT study, incident long-term opioid prescribing was more common among patients with OUDs than those with other SUDs or no SUD diagnoses. 61 In our data, these associations were particularly strong in the period immediately after the initiation of opioid therapy: Patients with OUDs and buprenorphine or naltrexone ...

Incident and long-term opioid therapy among patients with ...

Association of Opioid Usage with Spinal Cord Stimulation ...

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This study identified SCS patients using the Truven Health MarketScan databases from January 2010 to December 2014. The index event was the first occurrence of a permanent SCS implant. Indicators of opioid usage at implant were daily morphine equivalent dose (MED), number of unique pain drug classes, and diagnosis code for opioid abuse.

Association of Opioid Usage with Spinal Cord Stimulation ...

Progressive Opioid Use: Who’s At Risk? | Physician's Weekly

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The Consortium to Study Opioid Risks and Trends (CONSORT) is an initiative supported by the National Institute of Drug Abuse that has identified trends and risks associated with long-term opioid therapy for chronic pain. CONSORT classified opioid prescribing patterns as 1) short-term use, 2) episodic use, and 3) long-term use. Dr. Hooten and ...

Progressive Opioid Use: Who’s At Risk? | Physician's Weekly

Buprenorphine compared with methadone to treat pregnant ...

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The incidence of prescription and illicit opioid use during pregnancy has increased substantially in the United States since 2000, paralleling a similar escalation in the general population 1. Moreover, the prevalence of opioid use disorder (OUD) during pregnancy more than doubled between 1998 and 2011, to four per 1000 deliveries 2.

Buprenorphine compared with methadone to treat pregnant ...

CONSORT flow diagram for study 1 and study 2.Note: ITT ...

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CONSORT flow diagram for study 1 and study 2.Note: ITT consists of all randomized patients who had at least two visual analog scale pain intensity scores.Abbrev

CONSORT flow diagram for study 1 and study 2.Note: ITT ...
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