Candidate gene study design

Candidate gene - Wikipedia

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Most of the problems of candidate gene association studies can be circumvented by careful study design, including the assembly of cohorts of adequate sample size and statistical correction for confounding factors. Many of these issues are being addressed by the creation of large consortia to address the genetic contribution to various complex ...

Candidate gene - Wikipedia

Candidate Gene - an overview | ScienceDirect Topics

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9/6/2000 · The first step in designing a case-control study is to decide on the candidate gene or genes to be studied. Consideration should be given both to the relevance of the candidate gene to be studied to the pathogenesis of the particular disease and to the functional effects of a particular polymorphism.

Candidate Gene - an overview | ScienceDirect Topics

Candidate gene case-control association studies ...

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This protocol describes how to appropriately design a genetic association case-control study, either focussing on a candidate gene or region, or implementing a genome-wide approach. The steps described involve: 1) defining the case phenotype in adequate detail; 2) checking the heritability of the ...

Candidate gene case-control association studies ...

Designing candidate gene and genome-wide case-control ...

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5/9/2013 · The candidate gene approach has been a pioneer in the field of genetic epidemiology, identifying risk alleles and their association with clinical traits. With the advent of rapidly changing technology, there has been an explosion of in silico tools available to researchers, giving them fast, efficient resources and reliable strategies important to find casual gene variants for candidate or ...

Designing candidate gene and genome-wide case-control ...

Candidate gene association studies: a comprehensive guide ...

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A previous case-control candidate gene study of single nucleotide polymorphisms (SNPs) in 4 candidate genes (Fibronectin 1, type 9 collagen alpha 1 chain, type 9 collagen alpha 2 chain, and cartilage oligometric protein) failed to identify any significant associations between SNPs and the development of CCLR in a population of Newfoundland dogs ...

Candidate gene association studies: a comprehensive guide ...

Candidate Gene Study of Canine Joint Diseases | Journal of ...

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11/16/2012 · The purpose of this study is to conduct a candidate gene analysis of associations between BMI-related loci, weight, and detailed adiposity measures in older adults. M ethods Study Design and Participants. The Health, Aging and Body Composition Study (Health ABC) is a prospective study of 3,075 community-dwelling, initially well-functioning, AA ...

Candidate Gene Study of Canine Joint Diseases | Journal of ...

Candidate Gene Association Study of BMI-Related Loci ...

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This article outlines the design and analysis of genetic association studies, but it focuses specifically on case–control studies in candidate genes or regions. ... The International HapMap Project is a valuable resource for study design, ... This is a major issue in GWAS, but it is also applicable to candidate gene association studies ...

Candidate Gene Association Study of BMI-Related Loci ...

Introduction to Genetic Association Studies - CSH Protocols

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This protocol describes how to appropriately design a genetic association case–control study, either focusing on a candidate gene (CG) or region or implementing a genome-wide approach. The steps described involve: (i) defining the case phenotype in adequate

Introduction to Genetic Association Studies - CSH Protocols

Designing candidate gene and genome-wide case–control ...

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Part 2: Power for a candidate gene study. You may be curious as to the potential benefit of using a two-stage design to reduce costs when examining far fewer markers than those interrogated during a genome-wide association study, for example, when conducting a candidate gene study.

Designing candidate gene and genome-wide case–control ...

Power Calculator Tutorial -- Examplar Candidate Gene Study

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Study design. Based on the data published on www.clinicaltrials.gov, clopidogrel intervention studies containing genetic and platelet function data were identified for participation.Lead investigators were invited to share DNA samples, platelet function test results, patient characteristics, and cardiovascular outcomes to perform candidate gene and genome-wide studies.

Power Calculator Tutorial -- Examplar Candidate Gene Study

Genome-wide and candidate gene approaches of clopidogrel ...

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This protocol describes how to appropriately design a genetic association case-control study, either focussing on a candidate gene or region, or implementing a genome-wide approach. The

Genome-wide and candidate gene approaches of clopidogrel ...

Europe PMC Funders Group Wellcome Trust Centre for Human ...

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Population Stratification in the Candidate Gene Study: Fatal Threat or ... Because the case-control design is the most ... The candidate gene study, also known as an allelic association ...

Europe PMC Funders Group Wellcome Trust Centre for Human ...

Population Stratification in the Candidate Gene Study ...

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In genetics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait.

Population Stratification in the Candidate Gene Study ...

Genome-wide association study - Wikipedia

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11/14/2017 · The gene SMART (genes and the Skeletal Muscle Adaptive Response to Training) Study aims to identify genetic variants that predict the response to both a single session of High-Intensity Interval Exercise (HIIE) and to four weeks of High-Intensity Interval Training (HIIT). While the training and testing centre is located at Victoria University, Melbourne, three other centres have been launched ...

Genome-wide association study - Wikipedia

The gene SMART study: method, study design, and ...

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5/1/2002 · Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because …

The gene SMART study: method, study design, and ...

Candidate-gene approaches for studying complex genetic ...

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with a candidate gene study on childhood leukemia. MATERIALS AND METHODS Design options for genetic association studies The case-control design is a natural option for genetic association studies. For example, in candidate gene studies, genes with known functions potentially relevant to the eti-ology of the disease are studied; genotypes at ...

Candidate-gene approaches for studying complex genetic ...

Combining Case-Control and Case-Trio Data From the Same ...

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Editorial Commentary Still Building on Candidate-Gene Strategy in Hypertension? Fre´de´rique Tesson, Frans H.H. Leenen I n the general hypertensive population, blood pressure (BP) is a multifactorial trait, and it appears that hypertension results from increments in BP from a number of contributing robust biologically relevant pathways involved in sodium (Na⫹) transport affecting BP ...

Combining Case-Control and Case-Trio Data From the Same ...

(PDF) Still Building on Candidate-Gene Strategy in ...

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11/1/2008 · OBJECTIVE— Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene–based approach to identify single nucleotide polymorphism (SNP) variants in 222 candidate genes that influence susceptibility to type 2 diabetes. RESEARCH DESIGN AND METHODS— In a case-control study of 1,161 type 2 diabetic subjects and …

(PDF) Still Building on Candidate-Gene Strategy in ...

Comprehensive Association Study of Type 2 Diabetes and ...

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Candidate Gene Screening for Attention Deficit/Hyperactive Disorder (ADHD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Comprehensive Association Study of Type 2 Diabetes and ...

Candidate Gene Screening for Attention Deficit/Hyperactive ...

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7/4/2017 · A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate the effect of perinatal and socioeconomic factors on these associations. The anthropometry, socioeconomic and perinatal conditions and 10 polymorphisms were evaluated in 1081 young ...

Candidate Gene Screening for Attention Deficit/Hyperactive ...

Examining for an association between candidate gene ...

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we have not distinguished between these situations, The case-pseudosib design also appears to offer a taking as the parameter of interest the relative risk simple way to test G x E interactions: all one need do corresponding to the candidate gene or gene- Am J Epidemiol Vol. 149, No. 8, 1999 Case-Control Designs for Candidate Gene Studies 703 ...

Examining for an association between candidate gene ...

Asymptotic Bias and Efficiency In Case-Control Studies of ...

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yaspan.brian@gene.com Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study Amy Dressen*, Alexander R Abbas*, Christopher Cabanski, Janina Reeder, Thirumalai R Ramalingam, Margaret Neighbors, Tushar R ...

Asymptotic Bias and Efficiency In Case-Control Studies of ...

Analysis of protein-altering variants in telomerase genes ...

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10/24/2018 · The study design, patient population ... Twenty-one of these patients (22%) had at least one loss-of-function mutation in a candidate HRR gene, of whom 12 received olaparib and 9 received placebo.

Analysis of protein-altering variants in telomerase genes ...
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